ASTM F 2458 (F-2458) pertains to tissue adhesives which are becoming more prevalent in surgical procedures in replace of or alongside sutures or staples used in the biomedical industry. ASTM F2458 is a standardized test method for determining the wound closure strength of tissue adhesives or sealants. The mechanical properties of the adhesive substrate is important in evaluating the product and insuring quality control. There are various complexities of tissue adhesive devices and the methods in which they are used.Other related ASTM standards for this type of application include: ASTM F2255, F2256 and F2258.

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