ASTM F 2580 (F-2580) covers fatigue testing of metallic femoral hip prostheses used in hip joint replacements. This test method describes fatigue tests on metallic femoral hip stems using a cyclic, constant-amplitude force. It applies to hip prostheses that utilize proximal metaphyseal fixation and are of a modular construct, and it is intended to evaluate the fatigue performance of the modular connections in the metaphyseal filling (that is, proximal body) region of the stem. Other testing standards related to hip-joint prostheses include: ISO7206-4/6/8/9/10, ASTM F1820, ASTM F2009, ASTM F2582, and ASTM F2345.

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